lab publications
2023
Fu H., Vuononvirta J., Fanti S., Bonacina F., D’Amati A., Wang G., Poobalasingam T., Fankhaenel M., Lucchesi D., Coleby R., Tarussio D., Thorens B., Hearnden R., Longhi M.P., Grevitt P., Sheikh M.H., Solito E., Godinho SA., Bombardieri M., Smith D.M., Cooper D., Iqbal A., Rathmell J.C., Schaefer S., Morales V., Bianchi K., Norata G.D. and F.M. Marelli-Berg Marelli-Berg (2023). “The Glucose Transporter 2 regulates CD8+ T cell function via metabolic sensing”. Nature Metabolism, 5(11):1969-1985. Pubmed link
Monteiro P.*, Yeon B.*, Wallis S.S. and Godinho S.A. (2023). “Centrosome amplification fine-tunes tubulin acetylation to differentially control intracellular organization”. *Equal contribution. EMBO Journal, 42(16):e112812. Pubmed/BioRxiv Link
2022
Donker L. and Godinho S.A. (2022). “Too close for comfort? Endomembranes promote missegregation by enclosing lost chromosomes”. Journal of cell Biology, 221(6):e202204114. Pubmed link
2021
Adams S.D., Csere J., D’angelo G., Carter E., Arnandis T., Dodel M., Kocher H., Grose R., Raposo G., Mardakheh F. and Godinho S.A. (2021). “Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption”. Current Biology, 31(7):1403-1416. Research Highlights: making more exosomes. Nature Reviews in Molecular Cell Biology, 22, 242 (2021) and “What’s exciting the experts?” in Medical News Today Newsletter. Pubmed link/BioRxiv link
2020
Wilcz-Villega E., Carter E., Ironside A. Xu R., Mataloni I., Holdsworth J, Jones W., Bejar R.M., Uhlik L., Bentham R.B., Godinho S.A., Dalli J., Grose R., Szabadkai G., Jones L., Hodivala-Dilke K. & Bianchi K. (2020). “Macrophages induce malignant transformation of mammary epithelium via IKKe/TBK1 kinases and the serine biosynthesis pathway”. EMBO Molecular Medicine, 12(2):210491. Pubmed link
2019
Godinho S.A. (2019). “The principles of spindle bipolarity”. Nat Rev Mol Cell Biol. 20(6):325. Pubmed link
2018
Arnandis, T., Adams, S., Bridgeman, V., Rajeeve, V., Gadaleta, E., Marzec, J., Chalala, C., Malanchi, I., Cutillas, P. and Godinho S.A (2018). “Oxidative stress in cells with extra centrosomes drives non-cell autonomous invasion”. Developmental Cell, 47(4):409-424. Pubmed link
Monteiro P. and Godinho S.A. (2018). “Structural centrosomal abnormalities push cells toward invasion”. Preview. Developmental Cell, 45(3):286-288. Pubmed link
Marteil G., Guerrero A., Vieira A.F., de Almeida B.P., Mendonca S., Mesquita M. Vilareal B., Fonseca I., Francia M.E., Martins N.P. Jana S.C., Tranfield E.M., Barbosa-Morais N.L., Paredes J., Pellman D., Godinho S.A. and Bettencourt-Dias M. (2018). “Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation”. Nature Communications, 9(1):1258. Pubmed link
Rhys A.D., Monteiro P., Smith C., Veghela M., Arnandis T., Kato T., Leitinger B., Sahai E., McAinsh A., CHarras G. and Godinho S.A. (2018). “Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells”. Journal of Cell Biology, 217(1):195-209. Research Highlight: When E-cadherin is away, centrosomes can play. Journal of Cell Biology, 217(1). Selected to be part of the JCB 2018 issue “Year of Cell Biology”. Pubmed link
2017
Rhys A.D. and Godinho S.A. (2017). “Dividing with extra centrosomes: a double edge sword for cancer cells”. Review. Advances in Exp Med and Bio, 1002: 47-67. Pubmed link
Godinho S. (2017). “Centrosomes: PIDDosome join the counting game”. Dispatch. Current Biology, 27. Pubmed link
2015
Arnandis T. and Godinho S.A. (2015). “Studying centrosome function using three-dimensional cell cultures”. Methods in Cell Biology, 129:37-50. Pubmed link
Gibbons J.G., Branco A.T., Godinho S.A., Yu S. and Lemos B. (2015). “Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes”, PNAS, 112(8): 2485-90. Pubmed link
2014
Godinho S.A. (2014). “Centrosome amplification and cancer: Branching out”, Mol Cell Oncol., 2(1):2993252. Pubmed link
Godinho S.A. and David Pellman (2014). “Causes and Consequences of Centrosome Amplification in Cancer”, Review. Philos. Trans. R. Soc. Lond B Biolo. Sci, 369(1650). Pubmed link
Godinho S.A., Picone R., Burute M., Dagher R., Su Y., Leung C., Polyak K., Brugge J., Thery M. and Pellman D. (2014). “Oncogene-like induction of cellular invasion from centrosome amplification”, Nature, 510(7503):167-71. Featured in: Editor’s Choice: Centrosomes coordinate cancer invasion. Science Signaling, 7(329). Research Highlight: Extra centrosomes provide route to invasion. Nature Cell Biology, 16 (628). Pubmed link
2011
M. Bettencourt-Dias, F. Hildebrandt, D. Pellman, G. Woods and Godinho S.A. (2011). “Centrosomes in Human Disease”. Review. Trends in Genetics, 27(8):307-15. Pubmed link
2010
P. Vinciguerra, Godinho S.A., K. Pamar, D. Pellman and A.D. D’Andrea (2010). “Cytokinesis failure occurs in Fanconi Anemia pathway-deficient murine and human bone marrow hematopoietic cells”, Journal of Clinical Investigation, 120(11):3834-42. Pubmed link
2009
N.J. Ganem, Godinho S.A. and D. Pellman (2009). “A mechanism linking extra centrosomes to chromosomal instability”. Nature, 460(7252):278:82. Pubmed link
Godinho S.A.* & M. Kwon* and D. Pellman (2009).”Centrosomes and cancer: how cancer cells divide with too many centrosomes”. Review. Cancer and Metastasis Review, 28(1-2):85-99. * Equal contribution. Pubmed link
2008
M. Kwon* & Godinho S.A.*, N.S. Chandhok, N.J. Ganem, A. Azioune, M. Thery and D. Pellman (2008). “Mechanisms to suppress multipolar mitosis in cancer cells with extra centrosomes”. Genes&Development, 22: 2189-203. Cover. * Equal contribution. Featured in: Perspective: Multiple centrosomes: together they stand, divided they fail. Genes and Development, 22: 2291-6. Research Highlight: The counting game. Nature Reviews in Molecular Cellular Biology, 9: 669-669. Minireview: A tale of too many centrosomes. Cell, 134: 572-75. Preview: Actin and Microtubules: Working Together to Control Spindle Polarity. Cancer Cell, 14: 197-99. Pubmed link
Godinho S. and A. Tavares (2008), “A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis”, Cell Cycle 7: 2529-34. Pubmed link
2007
U. Schuller, Q. Zhao, Godinho S.A., V.M. Heine, R. H. Medema, D. Pellman and D.H. Rowitch (2007). “Function of forkhead transcription factor FoxM1 is required to regulate mitotic entry in cerebellar granule neuron percursors”, Molecular and Cellular Biology, 27: 8259-70. Pubmed link
2006
P. Alves* & Godinho S.A.* and A. Tavares (2006), “The Drosophila dPlkk is not essential for Polo activation but is necessary for proper contractile ring formation”, Experimental Cell Research, 312: 308-21. * Equal contribution. Pubmed link
Pearson J, Godinho S.A., A. Tavares and D.M. Glover (2006), “Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis”, Experimental Cell Research, 312: 770-81. Pubmed link